I’ve finally gotten around to Angular 2 development,

Barebones App

MyApp
├── app
│   ├── app.component.ts
│   ├── app.module.ts
│   └── main.ts
├──node_modules ...
├──index.html
├──package.json
├──style.css --optional
├──systemjs.config.js
└──tsconfig.json

package.json

{
  "name": "angular-quickstart",
  "version": "1.0.0",
  "scripts": {
    "start": "tsc && concurrently \"tsc -w\" \"lite-server\" ",
    "lite": "lite-server",
    "tsc": "tsc",
    "tsc:w": "tsc -w"
  },
  "licenses": [
    {
      "type": "MIT",
      "url": "https://github.com/angular/angular.io/blob/master/LICENSE"
    }
  ],
  "dependencies": {
    "@angular/common": "~2.1.1",
    "@angular/compiler": "~2.1.1",
    "@angular/core": "~2.1.1",
    "@angular/forms": "~2.1.1",
    "@angular/http": "~2.1.1",
    "@angular/platform-browser": "~2.1.1",
    "@angular/platform-browser-dynamic": "~2.1.1",
    "@angular/router": "~3.1.1",
    "@angular/upgrade": "~2.1.1",
    "angular-in-memory-web-api": "~0.1.13",
    "core-js": "^2.4.1",
    "reflect-metadata": "^0.1.8",
    "rxjs": "5.0.0-beta.12",
    "systemjs": "0.19.39",
    "zone.js": "^0.6.25"
  },
  "devDependencies": {
    "@types/core-js": "^0.9.34",
    "@types/node": "^6.0.45",
    "concurrently": "^3.0.0",
    "lite-server": "^2.2.2",
    "typescript": "^2.0.3"
  }
}

tsconfig.json

{
  "compilerOptions": {
    "target": "es5",
    "module": "commonjs",
    "moduleResolution": "node",
    "sourceMap": true,
    "emitDecoratorMetadata": true,
    "experimentalDecorators": true,
    "removeComments": false,
    "noImplicitAny": false
  }
}

systemsjs.config.js

(function (global) {
  System.config({
    paths: {
      'npm:': 'node_modules/'
    },
    map: {
      app: 'app',
      '@angular/core': 'npm:@angular/core/bundles/core.umd.js',
      '@angular/common': 'npm:@angular/common/bundles/common.umd.js',
      '@angular/compiler': 'npm:@angular/compiler/bundles/compiler.umd.js',
      '@angular/platform-browser': 'npm:@angular/platform-browser/bundles/platform-browser.umd.js',
      '@angular/platform-browser-dynamic': 'npm:@angular/platform-browser-dynamic/bundles/platform-browser-dynamic.umd.js',
      '@angular/http': 'npm:@angular/http/bundles/http.umd.js',
      '@angular/router': 'npm:@angular/router/bundles/router.umd.js',
      '@angular/forms': 'npm:@angular/forms/bundles/forms.umd.js',
      '@angular/upgrade': 'npm:@angular/upgrade/bundles/upgrade.umd.js',
      'rxjs': 'npm:rxjs',
      'angular-in-memory-web-api': 'npm:angular-in-memory-web-api/bundles/in-memory-web-api.umd.js'
    },
    packages: {
      app: {
        main: './main.js',
        defaultExtension: 'js'
      },
      rxjs: {
        defaultExtension: 'js'
      }
    }
  });
})(this);

Reference: